Klacid/Klacid MR Contraindications

Hypersensitivity to macrolide antibiotic drugs or any of the excipients (see DESCRIPTION).
Concomitant administration of clarithromycin and any of the following drugs is contraindicated: astemizole, cisapride, domperidone, pimozide, terfenadine as this may result in QT prolongation and cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation, and torsades de pointes (see INTERACTIONS).
Concomitant administration of clarithromycin and ergot alkaloids (e.g., ergotamine or dihydroergotamine) is contraindicated, as this may result in ergot toxicity (see INTERACTIONS).
Concomitant administration of clarithromycin and oral midazolam is contraindicated (see INTERACTIONS).
Clarithromycin should not be given to patients with history of QT prolongation (congenital or documented acquired QT prolongation) or ventricular cardiac arrhythmia, including torsades de pointes (see PRECAUTIONS and INTERACTIONS).
Clarithromycin should not be given to patients with electrolyte disturbances (hypokalemia or hypomagnesaemia, due to the risk of prolongation of the QT interval.
Clarithromycin should not be used in patients who suffer from severe hepatic failure in combination with renal impairment.
Clarithromycin should not be used concomitantly with HMG-CoA reductase inhibitors (statins), that are extensively metabolized by CYP3A4 (lovastatin or simvastatin), due to the increased risk of myopathy, including rhabdomyolysis (see PRECAUTIONS).
Clarithromycin (and other strong CYP3A4 inhibitors) should not be used concomitantly with colchicine (see PRECAUTIONS and INTERACTIONS).
Concomitant administration with ticagrelor or ranolazine is contraindicated.
Concomitant administration of clarithromycin and lomitapide is contraindicated (see INTERACTIONS).